Recombinant Human FGF-19

Fibroblast growth factor 19, also known as FGF19 is an atypical member of the fibroblast growth factor (FGF) family of proteins. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 uniquely binds to FGF receptor 4 (FGFR4).¹

The FGF19 subfamily has reduced heparin binding resulting from a disrupted beta-trefoil domain. Reduced heparin binding allows these FGFs to diffuse beyond their site of origin and act as endocrine hormones. This family of FGFs is regulated, at least in part, by nuclear hormone receptors.² Inactivation of FGF19 could be beneficial for the treatment of colon cancer, liver cancer and other malignancies involving interaction of FGF19 and FGFR4.³

The biological activity of Human FGF-19 was determined by its ability to bind rhFGF R4/Fc in a functional ELISA. Immobilized rhFGF R4/Fc at 2 μg/mL (100 μL/well) can bind rhFGF-19 with a linear range of 3 - 100 ng/mL.

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Leu25

Lyophilized

The predicted molecular weight of Recombinant Human FGF-19 is Mr 21 kDa.

21

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. French, DM. et al. (2008) Cancel Res. 68: 5086
2. Jones, S. et al. (2008) Mol Pharm. 5: 42
3. French, DM. et al. (2008) Oncogene 27: 85