CD28, is a key co-stimulatory molecule expressed on the surface of T cells, playing a pivotal role in initiating and amplifying T cell responses, ensuring a robust and effective immune reaction. Its primary function is to provide a crucial second signal for T cell activation. While the T cell receptor (TCR) recognizes the antigen presented by antigen-presenting cells (APCs), CD28 interacts with its ligands, CD80 (B7-1) and CD86 (B7-2), also on APCs. This co-stimulatory signal enhances T cell proliferation, cytokine production (particularly IL-2), and survival, effectively amplifying the immune response and ensuring a potent and sustained reaction to the antigen. Balancing co-stimulatory signals like CD28, which promote T cell activation, with co-inhibitory signals like CTLA-4 that dampen it is critical for maintaining immune homeostasis.
Dysregulation of CD28 signaling is implicated in various diseases, including autoimmune disorders, transplant rejection, and cancer, making understanding CD28’s role crucial for developing targeted therapies.
Building upon our expertise in CD28 and T cell co-stimulation, Leinco Technologies provides a comprehensive range of reliable CD28 antibodies and related products to support your research in critical areas:
- CD28/CD80/CD86 Pathway Studies: Uncover mechanisms of action for therapeutic interventions.
- T-Cell Activation Studies: Evaluating the impact of CD28 signaling on T cell proliferation, cytokine production, and overall immune function.
- Immune Checkpoint Research: Explore how immune regulation contributes to the development of novel immune checkpoint modulators.
- Autoimmune and Inflammatory Disease Research: Investigate the potential of CD28 modulation as a therapeutic target.
- Immunological Research: Advance fundamental understanding of T cell biology and immune cell interactions.
Explore our comprehensive catalog of CD markers for Flow Cytometry, IHC, and other research applications.
