Recombinant Mouse Cardiotrophin-1

Human CT-1 is a member of the IL-6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL-11, IL-6 and possibly NT-1/ BSF-3. CT-1 is a pleiotropic cytokine which signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Biologically active human CT-1 is synthesized as a 201 amino acid polypeptide lacking a hydrophobic N-terminal secretion signal sequence.

Human and mouse CT-1 share 80% aa sequence identity and exhibit cross-species activity.

sqregsled hqtdssisfl phleakirqt hnlarlltky aeqlleeyvq qqgepfglpg fspprlplag lsgpapshag lpvserlrqd aaalsvlpal ldavrrrqae lnpraprllr sledaarqvr algaavetvl aalgaaargp gpepvtvatl ftanstagif sakvlgfhvc glygewvsrt egdlgqlvpg gva

Ser2

Lyophilized

The predicted molecular weight of Recombinant Mouse CT-1 is Mr 21 kDa.

21

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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