Recombinant Mouse IL-17F

IL-17F, also known as C87042, is a homodimeric protein that is a member of the IL-17 family of cytokines produced by activated T cells and monocytes (1). IL-17F can stimulate production of other cytokines such as IL-6, IL-8 and G-CSF as well as regulate cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis (2). It is an important regulator of inflammatory responses that functions differently than IL-17 in immune responses and diseases (3). IL-17F inhibits the angiogenesis of endothelial cells and induces endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1 (4). Skin biopsy samples from psoriasis patients show the upregulation of IL-17F expression (5).

mailrevaar knpkagvpal qkagncpple dntvrvdiri fnqnqgisvp refqnrsssp wdynitrdph rfpseiaeaq crhsgcinaq gqedstmnsv aiqqeilvlr repqgcsnsf rlekmllkvg ctcv

Met

Lyophilized

The predicted molecular weight of Recombinant Mouse IL-17F is Mr 15 kDa.

15

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Starnes, T. et al. (2001) J. Immonol. 167:4137
2. Starovasnik, MA. et al. (2001) Embo. J. 20:5332
3. Dong, C. et al. (2008) J. Exp. Med. 205:1063
4. Starnes, T. et al. (2001) J. Immunol. 167:4137
5. Watanabe, H. et al. (2009) J. Invest. Dermatol. 129:650