Recombinant Mouse IL-17

Interleukin 17 (IL-17) is a T cell cytokine that induces monocyte migration and inflammation.¹ IL-17-producing cell could serve as a potential prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC).² IL-17 may be important in recruiting monocytes into the joints of patients with RA, supporting IL-17 as a therapeutic target in RA.¹

The biological activity of Mouse IL-17 was determined by its ability to induce IL-6 production by NIH/3T3 cells. The expected ED₅₀ for this effect is typically 0.25 - 1.25 ng/ml.

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Thr22

Lyophilized

The predicted molecular weight of Recombinant Mouse IL-17A is Mr 15.5 kDa.

15.5

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Pope, RM. et al. (2009) J Immunol. 182: 3884
2. Zheng, L. et al. (2009) J Hepatol. 50(5):980-989.