Recombinant Human Interleukin-17 receptor (IL-17 R)

Interleukin-17 receptor (IL-17R), also known as CD217, is a cytokine receptor which binds interleukin-17 (1). Functional IL-17R is a heteromeric complex consisting of at least IL17RA and IL17RC (2). IL-17R is expressed on a wide range of hematopoietic and non-hematopoietic tissues and cell lines, as well as cord blood lymphocytes, peripheral blood lymphocytes and thymocytes. Expression is also on B, T and NK cells, fibroblasts, epithelial cells, monocytes, macrophages and granulocytes. IL-17R signaling is critical for pulmonary neutrophil recruitment and host defense against Gram-negative bacteria through the coordinated release of G-CSF and CXC chemokine elaboration (3). IL-17/IL-17R play a critical role in regulating host susceptibility to Chlamydia infection in mice (4).

Fc Fusion Protein

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Leu33

Lyophilized

The predicted molecular weight of Recombinant Human IL-17 R is Mr 60 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 100 kDa.

60

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Yao, Z. et al. (1997) Cytokine 9:794
2. Toy, D. et al. (2006) J. Immunol. 177:36
3. McAlister, F. et al. (2005) J. Immunol. 175:404
4. Wang, J. et al. (2009) Infect. Immun. 77:5059