Alpha Crystallin B (11073MP)
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Antibody DetailsProduct DetailsReactive Species Mouse Product Concentration Lot Specific Formulation Sterile-filtered colorless solution contains 20mM Tris buffer, pH 8.0 and 10% glycerol. State of Matter Liquid Storage and Handling Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below -20°C for longer periods of time. For long term storage, addition of a carrier protein (0.1% HSA or BSA) is recommended. Country of Origin USA Shipping Next Day 2-8°C Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Recombinant Mouse Alpha Crystallin B Background Alpha crystallins are composed of two gene products: alpha-A (acidic) and alpha-B (basic). Alpha crystallins are induced by heat shock and are members of the small heat shock protein family. They act as molecular chaperones. In addition, alpha crystallins have autokinase activity and play a role in intracellular architecture. Alpha crystallin B is expressed in many tissues and is associated with many neurological diseases. Function May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (PubMed:31786107). {PubMed:31786107}. References & CitationsTechnical Protocols Certificate of Analysis |
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