Anti-α-1-antichymotrypsin Antibody (13801)

Purified human serum alpha-1-antichymotrypsin.

This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added.

Liquid

Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Upon initial thawing, appropriately aliquot and store at -80°C. For long-term storage, keep at -80°C. Avoid repeated freeze-thaw cycles.

Next Day 2-8°C

These antibodies specifically recognize human serum alpha-1-antichymotrypsin. They do not cross-react with alpha-1-antitrypsin.

Alpha 1-antichymotrypsin (alpha1AC) is an alpha globulin glycoprotein produced in the liver that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. alpha1AC inhibits the activity of proteases such as cathepsin G from neutrophils and chymases from mast cells by cleaving them into different conformations. This activity protects tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. alpha1AC is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease, and mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. It is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils.

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. {PubMed:2404007}.