Anti-Bovine PKC-Biotin
Anti-Bovine PKC-Biotin
Product No.: P108
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Clone MC5 Target Protein Kinase C Formats AvailableView All Product Type Monoclonal Antibody Isotype IgG2a Applications IHC FF , WB |
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Antibody DetailsProduct DetailsReactive Species Bovine Host Species Mouse Product Concentration 0.5 mg/ml Formulation This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2831508 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Anti-Protein Kinase C (PKC) recognizes the intact (Mr 79-80 kDa) calcium-activated, phospholipid-dependent Protein Kinase C in bovine brain. The antibody strongly cross-reacts with PKC in human, mouse and rat cells.1 Anti-PKC (clone MC5) binds to an epitope at the hinge region of the enzyme, the site of phorbol-ester-induced proteolysis which is thought to down-regulate PKC activity in intact cells.1,2 Monoclonal MC5 reacts with PKC-α/ß1/ß2 isoforms. Background Anti-PKC-Biotin (clone MC5) may be used to block both proteolysis and down-regulation of PKC activity. The antibody reacts with the intact molecule and may be used to localize PKC activity and to study the role of proteolysis in the activation of the Protein Kinase C pathway. Research Area Apoptosis . Cell Biology . Immunology References & Citations1. Young, S. et al. (1988) Eur. J. Biochem. 172:247 2. Young, S. et al. (1987) Biochem. J. 244:775 Technical ProtocolsIHC FF  Certificate of Analysis |
Formats Available
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Prod No. | Description |
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P321 | |
P322 | |
P323 | |
P325 | |
P326 | |
P327 | |
P107 | |
P108 | |
P109 | |
P110 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
