Anti-Cytokine Receptor-like Factor 2 Antibody (90011)
Anti-Cytokine Receptor-like Factor 2 Antibody (90011)
Product No.: 90011
- -
- -
Clone 8H8 Target Cytokine Receptor-like Factor 2 Formats AvailableView All Product Type Monoclonal Alternate Names Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor Isotype IgG1 Applications ELISA , IHC , WB |
Data
Immunohistochemistry: Formalin-fixed,
paraffin-embedded tissue. Use at 1-
10ug/ml. - -
- -
Antibody DetailsProduct DetailsReactivity Species Human Host Species Mouse Immunogen Recombinant human TSLPR- Fc fusion protein. Accession no. Q9HC73. Formulation Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml. State of Matter Lyophilized Product Preparation Purified by Protein A affinity chromatography Storage and Handling This product is stable for at least one (1) year at -20°C to -70°C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco ELISA: use at 0.05-0.10ug/ml.
Immunoblotting: use at 0.5-1ug/ml. A band of ~42kDa is detected. Immunohistochemistry: Formalin-fixed, paraffin-embedded tissue. Use at 1- 10ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their applications. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Monoclonal Antibody specific to Cytokine Receptor-Like Factor 2 Background Cytokine Receptor-like Factor 2, also known as thymic stromal lymphopoietin protein receptor (TSLPR), is the product of the CRLF2 gene. The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. Antigen DetailsFunction Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. {PubMed:11418668}. NCBI Gene Bank ID UniProt.org Research Area Growth Factors, Cytokines, Receptors References & CitationsTechnical Protocols   |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
