Anti-Endothelin Antibody (19403)

Anti-Endothelin Antibody (19403)

Product No.: 19403


Clone ENDO 20-2125.4 Target Endothelin Formats AvailableView All Product Type Monoclonal Alternate Names Preproendothelin-1, PPET1 [Cleaved into: Endothelin-1] Isotype Mouse IgG1 Applications ELISA , IHC , WB


Select Product Size 100 µg — $482.00	Qty Max: Min: 1 Step: 1 $482.00 ADD TO CART Login For mAb Advantage Pricing Contact Us for Bulk Quantities

Data


Antibody Details Product Details Reactive Species Human Host Species Mouse Immunogen Human endothelin-1 (ET-1) Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by Protein G affinity chromatography Storage and Handling These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunohistochemistry:Paraffin-embedded rat kidney exposed to 60 minutes of ischemia. ET-1 expression is seen in the endothelium of the peritubular capillary network (arrows, dark reaction product) with #19401 at 5-20ug/ml. Wilhelm SM et al. 1999 Kidney International 55: 1011-1018.ELISA:use at 5-20ug/ml with endothelin-1 on the solid phase. These are recommended concentrations. Endusers should determine optimal concentrations for their applications. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Specificity Mouse Monoclonal Antibody specific to Endothelin Function Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). {UniProtKB:P09558, PubMed:17446437, PubMed:19086031}. NCBI Gene Bank ID EDN1 UniProt.org P05305 Research Area Hormones/Proteins References & Citations View product citations for antibody PRODUCT_CODE on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Mouse

Immunogen

Human endothelin-1 (ET-1)

Product Concentration

Lot Specific

Formulation

PBS, pH 7.4.

State of Matter

Liquid

Product Preparation

Purified by Protein G affinity chromatography

Storage and Handling

These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Country of Origin

USA

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunohistochemistry:Paraffin-embedded rat kidney exposed to 60 minutes of ischemia. ET-1 expression is seen in the endothelium of the peritubular capillary network (arrows, dark reaction product) with #19401 at 5-20ug/ml. Wilhelm SM et al. 1999 Kidney International 55: 1011-1018.ELISA:use at 5-20ug/ml with endothelin-1 on the solid phase.

These are recommended concentrations.

Endusers should determine optimal concentrations for their applications.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Mouse Monoclonal Antibody specific to Endothelin

Function

Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). {UniProtKB:P09558, PubMed:17446437, PubMed:19086031}.

NCBI Gene Bank ID

EDN1

UniProt.org

P05305

Research Area

Hormones/Proteins