Anti-Epidermal Growth Factor-like Protein 7 Antibody (90013)
Anti-Epidermal Growth Factor-like Protein 7 Antibody (90013)
Product No.: 90013
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Clone 2H2 Target Epidermal Growth Factor-like Protein 7 Formats AvailableView All Product Type Monoclonal Alternate Names EGF-like protein 7, Multiple epidermal growth factor-like domains protein 7, Multiple EGF-like domains protein 7, NOTCH4-like protein, Vascular endothelial statin, VE-statin, Zneu1 Isotype IgG1 Applications ELISA , IHC , WB |
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Antibody DetailsProduct DetailsReactivity Species Human Host Species Mouse Immunogen His-tagged EGFL-7 recombinant protein. Accession no. Q9UHF1. Formulation Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml. State of Matter Lyophilized Product Preparation Purified by Protein A affinity chromatography Storage and Handling This product is stable for at least one (1) year at -20°C to -70°C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco ELISA: use at 1-10ug/ml
Immunoblotting: User should use at 1-5ug/ml. A band of ~30kDa is detected. Immunohistochemistry: Use at 2- 10ug/ml. These are recommended concentrations. End user should determine optimal concentrations for their applications. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Monoclonal Antibody specific to Epidermal Growth Factor-like Protein 7 Background EGF-L7 (Epidermal Growth Factor Like Protein 7) is a multi-domain protein containing two EGF like domains and one EMI domain. It is expressed almost exclusively in endothelial cells and functions to promote normal development of the vascular system. EGF-L7 is capable of antagonistic binding to Notch receptors resulting in the inhibition of Notch signaling in HUVEC and neural stem cells. In research models inducing hypoxia and subsequent reoxygenation, (H/R), EGF- L7 can inhibit ICAM-1 expression and enhance the inhibition of NF-kappaB activation. Additionally, EGF-L7 is a chemoattractant for endothelial cells and binds to the extracellular matrix. The overexpression of EGF-L7 is observed in various cancers, and is generally correlated with increased metastasis and a poor prognosis. Antigen DetailsFunction Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. {PubMed:23386126, PubMed:23639441}. NCBI Gene Bank ID UniProt.org Research Area Growth Factors, Cytokines, Receptors References & CitationsTechnical Protocols   |
Formats Available
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Prod No. | Description |
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56605 | |
90013 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
