Anti-Human BAFF-R (CT)

Purified Recombinant Human BAFF-R (>98%)

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human B Cell Activating Factor (BAFF-R) recognizes Human BAFF-R. This polyclonal antibody was purified using affinity chromatography.

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4.^1-4 BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion.^1,2 Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase.⁴

1. Moore, P. A. et al. (1999) Science 285:260 2. Schneider, P. et al. (1999) J. Exp. Med. 189:1747 3. Shu, H. B. et al. (1999) J. Leukoc. Biol. 65:680 4. Mukhopadhyay, A. et al. (1999) J. Biol. Chem. 274:15978