Anti-Human CARMA1

PN:C1231

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human CARMA1 recognizes an epitope near the C-terminus of human and mouse CARMA1. This polyclonal antibody was purified using affinity chromatography.

CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules.¹ CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types.^2,3 Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I/K complex, thereby regulating activation of the NF-κB transcription factor.⁵ Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.⁶

1. Fanning, AS. and Anderson, JM. (1999) Curr. Opin. Cell Biol. 11:432-9.
2. Gaide, O. et al. (2001) FEBS Lett. 496:121-7.
3. Bertin, J. et al. (2001) J. Biol. Chem. 276:11877-82.
4. McAllister-Lucas, LM. et al. (2001) J. Biol. Chem. 276:30589-97.