Anti-Human Casp-4 (Intermediate Domain)

PN:C1269

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Casp-4 recognizes an epitope in the intermediate domain of Human Casp-4. This polyclonal antibody was purified using affinity chromatography.

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.¹ Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18.^2,3 Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells.⁴ More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer’s disease.⁵

1. Martinon, F. and Tschopp, J. (2004) Cell 117:561-74.
2. Flavell, RA. et al. Science 267:2000-3.
3. Gracie, JA. et al. (2003) J. Leukoc. Biol. 73:213-224.
4. Ghayur, T. et al. (1995) J. Biol. Chem. 270:15250-6.