Anti-Human Caspase-6 (Intermediate Domain)

PN:C1273

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Caspase-6 recognizes an epitope in the intermediate domain of Human Caspase-6. This polyclonal antibody was purified using affinity chromatography.

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.^1,2 The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death.³ Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3.⁴ It possesses two isoforms, of which only the longer form possesses protease activity.⁴ Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies.⁵

1. Martinon, F and Tschopp, J. (2004) Cell 117:561-74.
2. Zhivotovsky, B. and Orrenius, S. (2005) Biochim. Biophys. Res. Comm. 331:859-67.
3. Wolf, BB. and Green, DR. (1999) J. Biol. Chem. 274:20049-52.
4. Fernandes-Alnemri ,T. et al. (1995) Cancer Res. 55:2737-42.