Anti-Human CCL23
Anti-Human CCL23
Product No.: M181
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Target CCL23 Product Type Polyclonal Antibody Alternate Names Chemokine (C-C Motif) Ligand 23, SCYA23, Ckb-8, Myeloid Progenitor Inhibitory Factor-1 (MPIF-1), MIP-3, CKb8, HMRP-2A (Human MIP-Related Protein 2A) Applications N , WB |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen Purified Recombinant Human CCL23 (>98%) Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This antigen affinity purified polyclonal antibody is aseptically filtered and lyophilized from PBS with no carrier proteins or preservatives added. State of Matter 0.5-2.0 Storage and Handling The lyophilized antibody should be stored desiccated at -20°C. The reconstituted antibody can be stored for at least six weeks at 4°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831365 Applications and Recommended Usage? Quality Tested by Leinco Western Blotting: To detect Human CCL23 this polyclonal antibody can be used at a concentration of 0.1 - 0.2 µg/ml. This polyclonal antibody should be used in conjunction with compatible second-step reagents such as PN:R1190 and a chromogenic substrate such as PN:T343. The detection limit for Human CCL23 is 5 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. A suitable Western blotting control is PN:M180. Additional Applications Reported In Literature ? Neutralization: This antibody is useful for neutralization of Human CCL23 bioactivity. The antibody dose required to neutralize 50% (ND50) of the biological activity of Human CCL23 (at 20 ng/ml) is 0.5 - 2.5 µg/ml. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Human Chemokine (C-C Motif) Ligand 23 (CCL23) recognizes Human CCL23. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research. Background Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family.1 It is primarily expressed in cells of the myeloid lineage.2 CCL23 induces endothelial cell migration and tube formation and enhances the expression of MMP-2 mRNA and protein levels in endothelial cells. CCL23 may play a direct role in angiogenesis.3 PubMed NCBI Gene Bank ID UniProt.org Research Area Chemokine References & Citations1. Huang, SA. et al. (2007) J Experimental Hematol. 15: 496 2. Woisetschläger, M. et al. (2007) J Immunol 178: 4335 3. Kim, J. et al. (2006) Biochemical and biophysical res communications 340:498 Technical ProtocolsN  Certificate of Analysis |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
