Anti-Human CD14 – APC

This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

This APC conjugate is stable when stored at 2-8°C. Do not freeze.

Next Day 2-8°C

Red Laser (650 nm)

Clone UCHM-1 recognizes an epitope on human CD14.

CD14 is a 53-55 kD GPI-anchored single chain glycoprotein that plays a role in the clearance of gram-negative pathogens by interacting with other proteins, including TLR-4 and MD-2, to mediate the innate immune response to bacterial lipopolysaccharide (LPS). As a high-affinity receptor for LPS, it is involved in the upregulation of adhesion molecules and cytokine expression in monocytes and neutrophils.

CD14 is expressed on monocytes, macrophages, dendritic cells, and granulocytes.

LPS

1. Ulrich Costabel et al. (1995) CHEST 108: 1614 2. Ulevitch RJ et al. (1993) Immunobiology 187: 227 3. Schumann RR et al. (1994) Medical Microbiol Immunol. 183: 279 4. Verhasselt V et al. (1997) J Immunol. 158: 2919 5. Kirkland TN et al. (2000) J Biol Chem. 275: 3144