Anti-Human CD14 – Biotin
Anti-Human CD14 – Biotin
Product No.: C154
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Clone UCHM-1 Target CD14 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names P35 Isotype IgG2a Applications FC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Product Concentration 0.5 mg/ml Formulation This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day Ambient RRIDAB_2828609 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this UCHM-1 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone UCHM-1 recognizes an epitope on human CD14. Background CD14 is a 53-55 kD GPI-anchored single chain glycoprotein that plays a role in the clearance of gram-negative pathogens by interacting with other proteins, including TLR-4 and MD-2, to mediate the innate immune response to bacterial lipopolysaccharide (LPS). As a high-affinity receptor for LPS, it is involved in the upregulation of adhesion molecules and cytokine expression in monocytes and neutrophils. Antigen Distribution CD14 is expressed on monocytes, macrophages, dendritic cells, and granulocytes. Ligand/Receptor LPS PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Biology . Immunology . Neuroinflammation . Neuroscience References & Citations1. Freyssinet, JM et al. (1997) J Clin Invest. 99(7): 1546–1554. PubMed 2. Ulrich, Costabel et al. (1995) CHEST 108: 1614 3. Ulevitch, RJ et al. (1993) Immunobiology 187: 227 4. Schumann, RR et al. (1994) Medical Microbiol Immunol. 183: 279 5. Verhasselt, V et al. (1997) J Immunol. 158: 2919 6. Kirkland, TN et al. (2000) J Biol Chem. 275: 3144 Technical Protocols Certificate of Analysis |
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C153 | |
C154 | |
C155 | |
C1859 | |
C1860 | |
C1861 | |
C1863 | |
C1865 | |
C156 | |
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C315 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
