Anti-Human CD25 (IL-2Rα) – Purified
Anti-Human CD25 (IL-2Rα) – Purified
Product No.: C9310
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Clone 7G7B6 Target CD25 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names IL-2Rα, CD25, Ly-43, p55, Tac Isotype IgG2a Applications ELISA , FC , IF Staining , IP , WB |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Recombinant human peripheral blood mononuclear cells (PBMCs) Product Concentration 0.5 mg/ml Formulation This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2829884 Applications and Recommended Usage? Quality Tested by Leinco ELISA FC WB Additional Applications Reported In Literature ? IF IP Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 7G7B6 reacts with human IL-2Rα. Background CD25 (IL-2Rα) is the 55 kDa subunit of the interleukin 2 receptor alpha chain which has been shown to play roles in lymphocyte differentiation, activation, and proliferation. IL-2Rα is a transmembrane glycoprotein comprised of a heavily glycosylated extracellular domain, a transmembrane region and a short cytoplasmic tail. IL-2Rα heterodimerizes with IL-2Rβ (CD122) and IL-2Rγ (CD132) and forms the IL-2 receptor complex. IL-2Rα by itself binds IL-2 with relatively low affinity, while the IL-2 receptor complex binds IL-2 with high affinity. IL-2Rα mutations cause severe immunodeficiency. Antigen Distribution IL-2Rα is expressed on activated mature T and B lymphocytes, during early stages of thymocytes development, pre-B cells, and in activated CD4+ memory T-lymphocytes. PubMed NCBI Gene Bank ID UniProt.org Research Area Immunology References & Citations1. Xi, X. et al. (2016) Front. Med. 10(3): 311–319 2. Hong, X. et al.(2015) Biochim Biophys Acta. 1853(2):489-99 Technical Protocols  IF Staining   Certificate of Analysis |
Formats Available
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
