Anti-Human CD28 – Purified in vivo PLATINUM™ Functional Grade

Mouse IgG1 PLATINUM, Clone hksp OR Mouse IgG1 PLATINUM, Clone hksp84

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.

This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Next Day 2-8°C

Clone CD28.2 recognizes an epitope on human CD28.

CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic.

CD28 is expressed on thymocytes, CD4+, CD8+ peripheral T cells, NK cells.

CD80, CD86

1. Stern, LJ. et al. (2005) Proc Natl Acad Sci U S A.102(10):3744-9 PubMed