Anti-Human CD62L – Purified (PhenoCyler-Fusion (CODEX)® Ready)
Anti-Human CD62L – Purified (PhenoCyler-Fusion (CODEX)® Ready)
Product No.: C512
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Clone DREG56 Target CD62L Formats AvailableView All Product Type Monoclonal Antibody Alternate Names TQ1, LAM1, LEU8, LNHR, LSEL, CD62L, LYAM1, PLNHR, LECAM1 Isotype IgG1 Applications IHC FF , PhenoCycler® |
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CODEX® DetailsValidation Notes Clone DREG56 has been validated for use on CODEX® using human tonsil Fresh Frozen (FF) tissue. Tissue Screened Tonsil Tissue Preparation FF (Fresh Frozen) Antibody and Reporter DetailsReactivity Species Human Host Species Mouse Concentration 0.5 mg/ml Formulation This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4. Storage and Handling This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Applications and Recommended Usage? Quality Tested by Leinco CODEX® This CD62L (Clone DREG56) antibody is formulated to simplify the antibody preparation needed when performing a CODEX® barcode conjugate. The suggested concentration is 0.5 mg/ml. RRID AB_2893569 Country of Origin USA Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Clone DREG56 recognizes an epitope on human CD62L. Antigen Distribution CD62L is expressed on most circulating leukocytes, including neutrophils, monocytes, T, B and NK cells, and human embryo trophoblasts. Background CD62L antibody, clone DREG56, recognizes CD62L, also known as L-selectin or LECAM-1, a 74-95 kDa type I transmembrane glycoprotein and cell adhesion molecule expressed on most circulating leukocytes1. Ligands for CD62L include CD34, GlyCAM-1, and MAdCAM-1, which require sialyation, fucosylation, and carbohydrate sulfation for recognition2,3. Ligand binding mediates tethering and rolling of leukocytes, facilitating entry into secondary lymphoid organs, including lymph nodes and Peyer’s patches, via high endothelial venules (HEVs)1. CD62L is also expressed on human embryo trophoblasts and has been proposed to play a role in human embryo implantation4.
Antigen DetailsProtein Ligand/Receptor CD34, GlyCAM, MAdCAM-1 Function Leukocyte homing, leukocyte tethering, rolling PubMed NCBI Gene Bank ID References & Citations1. Ivetic A, et al. (2019) Front Immunol. 10:1068 2. Varki A (1994) Proc Natl Acad Sci USA. 91(16):7390-7397 3. Rosen SD. (1999) Am J Pathol. 155(4):1013-1020 4. Genbacev OD, et al. (1003) Science. 299(5605):405-8 Technical Protocols PhenoCycler® |
Formats Available
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Prod No. | Description |
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C2275 | |
C2271 | |
C2140 | |
C2276 | |
C2277 | |
C2278 | |
C2279 | |
C512 | |
C2274 | |
C2270 | |
C2273 | |
C2272 | |
C6270 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
