Anti-Human Collapsin Response Mediator Protein 1 (CT) (CRMP1)

PN:C1302

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Collapsin Response Mediator Protein 1 (CRMP1) recognizs an epitope near the C-terminus of Human, Mouse and Rat CRMP1. This polyclonal antibody was purified using affinity chromatography.

Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis.¹ Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity.² CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain³; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth.⁴ CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.

1. Charrier, E. et al. (2003) Mol. Neurobiol. 28:51 2. Cameron, H. A. et al. (2001) J. Comp. Neurol. 435:406 3. Hamajima, N. et al. (1996) Gene 180:157 4. Quach, T. T. et al. (2004) Mol. Cell. Neurosci. 25:433