Anti-Human CTRP6 (CT)

PN:C1294

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human CTRP6 recognizes an epitope near the C-terminus of Human and Mouse CTRP6. This polyclonal antibody was purified using affinity chromatography.

Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-related proteins (CTRPs) 1-7.² Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues.³ These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene.⁴ CTRP6 contains at least 4 glycosylation motifs, suggesting that CTRP6 may be highly post-translationally modified.³

1. Fantuzzi, G. (2005) J. Allergy Clin. Immunol. 115:911
2. Tsao, TS. et al. (2002) Euro. J. Pharmacol. 440:213
3. Wong, GW. et al. (2004) Proc. Natl. Acad. Sci. USA 101:10302
4. Shapiro, L. et al. (1998) Curr. Biol. 8:335