Anti-Human Hepsin (Clone 2D5) – Purified
Anti-Human Hepsin (Clone 2D5) – Purified
Product No.: H4410
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Clone 2D5 Target Hepsin Formats AvailableView All Product Type Monoclonal Antibody Alternate Names HPN, TMPRSS1, 2D5-1.9, 2D5.1.9 Isotype IgG2a κ Applications ELISA , FC , WB |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Human hepsin protein Product Concentration 0.5 mg/ml Formulation This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2830334 Applications and Recommended Usage? Quality Tested by Leinco ELISA FC WB Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 2D5 recognizes Human hepsin. It binds to a separate epitope than clone 3H10.1. These clones do not interfere with one another. Background Hepsin is a type II transmembrane serine protease (TTSP) expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues. The physiological function of hepsin is unclear, although, In vitro studies have shown that hepsin activates blood clotting factors VII, XII, and IX, pro-urokinase (pro-uPA), and pro-hepatocyte growth factor (pro-HGF). The over-expression of hepsin has been implicated in several types of cancer, especially ovarian and prostate, which makes it an attractive diagnostic marker for cancers. Most notably, hepsin has been identified as one of the most highly induced genes in prostate cancer, and this over-expression is correlated with the cancer progression and metastasis. Furthermore anti-hepsin antibodies have been shown to inhibit the invasion of human prostate cancer cells.1 Antigen Distribution Hepsin is expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues. PubMed NCBI Gene Bank ID UniProt.org Research Area Immuno-Oncology References & Citations1. Wu, Q. and Parry, G. (2007) Front Biosci 12 5052-9 Technical Protocols   Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
