Anti-Human IL-1RAcP (CT-2)

PN:I-319

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human IL-1 Receptor Accessory Protein (IL-1RAcP) recognizes an epitope near the C-terminus of Human IL-1RAcP. This polyclonal antibody was purified using affinity chromatography.

IL-1R accessory protein (IL-1RAcP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL-1-dependent activation of transcription factors and gene expression.¹ IL-1R AcP represents a novel target for blocking IL-1 function in human disease.²

1. Martin, MU. et al. (1997) J Biol Chem. 272: 7727
2. Labow, MA. et al. (1998) J Immunol. 161: 5614