Anti-Human IL-21 (Intermediate Domain)

PN:I-353

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Interleukin-21 (IL-21) recognizes an epitope in the intermediate domain of Human IL-21. This polyclonal antibody was purified using affinity chromatography.

Interleukin 21 (IL-21) is a T cell-derived pleiotropic cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.^1,2 This cytokine induces cell division/proliferation in its target cells. IL-21 elicits its effects on immune cells by interacting with a cell surface receptor known as the interleukin 21 receptor, IL-21R, which is expressed in bone marrow cells and various lymphocytes. IL-21 is closely related to IL-2 and IL-15³ and is a key factor in the transition between innate and adaptive immune responses.⁴ The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.⁵

1. Foster D et al. (2000) Nature 408: 57
2. Clegg CH et al. (2002) J. Leukoc. Biol. 72: 856
3. Leonard WJ.et al. (2002) Science 298: 1630
4. Joannopoulos K.et al. (2003) J. Immunol. 171: 608
5. Lipsky PE. et al. (2008) Ann Rheum. Dis. 3: 83