Anti-Human IL-21R (Extracellular Domain)

PN:I-355

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

Rabbit Anti-Human Interleukin-21 Receptor (IL-21R) recognizes an epitope in the extracellular domain of Human, Mouse and Rat IL-21R. This polyclonal antibody was purified using affinity chromatography.

Interleukin 21 receptor (IL-21R) is a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene (IL4RA).¹ IL-21R is an important amplifier of alternative macrophage activation. Collectively, these results illustrate an essential function for the IL-21R in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases.² IL-21/IL-21R system may represent a new target for the treatment of Adult T-cell leukaemia (ATL).³

1. Hackstein H et al. (2003) Genes Immun. 4: 228 2. Wynn TA et al. (2006) J Clin Invest. 116: 2044 3. Uchiyama T et al. (2005) Br J Haematol. 128: 169