Anti-Human IL-4 – APC
Anti-Human IL-4 – APC
Product No.: I-1166
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Clone MP4-25D2 Target IL-4 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names BCGF, BCDF, B Cell Stimulating Factor, BSF-1 Isotype IgG1 Applications FC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rat Immunogen Purified Recombinant Human IL-4 (>98%) Formulation This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative. Product Preparation The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. Storage and Handling This APC conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Red Laser (633 nm) RRIDAB_2830506 Applications and Recommended Usage? Quality Tested by Leinco Flow Cytometry:For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. NOTE: The clone is also useful for intracellular immunofluorescent staining and flow cytometric analysis to identify IL-4 -producing cells within mixed cell populations. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone MP4-25D2 recognizes human IL-4. Background IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients. PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Biology . Immunology . Neuroinflammation . Neuroscience . Other Molecules References & Citations1. Pike, JW. et al. (2001) PNAS 98: 2443 2. Finkelman, FD. et al. (2003) J Immunol. 170: 3835 3. Kaplan, MH. et al. (2008) J Immunol. 180: 3551 Technical Protocols Certificate of Analysis |
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Formats Available
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Prod No. | Description |
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I-1167 | |
I-1163 | |
I-1166 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
