Anti-Human Interferon Regulatory Factor 7 (CT)

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Interferon Regulatory Factor 7 (IRF7) recognizes an epitope near the C-terminus of human, mouse and rat IRF7. This polyclonal antibody was purified using affinity chromatography.

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, hostvirus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-α/β genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes (2). IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3,4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.

1. Malmgaard, L. (2004) J. Interferon & Cyto. Res. 24:439
2. Sato, M. et al. (2000) Immunity 2000 13:539
3. Fitzgerald, KA. et al. (2003) J. Exp. Med. 198:1043
4. Honda, K. et al. (2004) Proc. Natl. Acad. Sci. USA 101:15416