Anti-Human Lano (CT)

PN:L177

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Lano recognizes an epitope near the C-terminus of Human Lano. This polyclonal antibody was purified using affinity chromatography.

Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble.¹ The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells.² Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions.^1,3 It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues.⁴

1. Saito, H. et al. (2001) J. Biol. Chem. 276:32051
2. Legouis, R. et al. (2003) EMBO Rep. 4:1096
3. Funke, L. et al. (2005) Annu. Rev. Biochem. 74:219
4. Bilder, D. et al. (2000) Nature 403:676