Anti-Human MD-1 (Intermediate Domain)

PN:M1223

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human MD-1 recognizes an epitope near the center of human, mouse and rat MD-1. This polyclonal antibody was purified using affinity chromatography.

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1). The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway (2). While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes (4).

1. Takeda, K. et al. (2003) Annu. Rev. Immunol. 21:335
2. Divanovic, S. et al. (2005) J. Endotoxin Res. 11:363
3. Tsuneyoshi, N. et al. (2005) J. Immunol. 174:340
4. Nagai, Y. et al. (2005) J. Immunol. 174:7043