Anti-Human Persephin

Purified Recombinant Human PSP (>98%)

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

Lyophilized

The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Next Day Ambient

Rabbit Anti-Human Persephin (PSP) recognizes Human PSP. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

Persephin (PSP) is a secreted protein belonging to the glial cell line-derived neurotrophic factor (GDNF) family of the TGF-b superfamily. Just like factor GDNF and neurturin (NTN), PSP promotes the survival of ventral midbrain dopaminergic neurons and prevents their degeneration. Persephin also supports the survival of motor neurons.¹ Persephin is expressed at very low levels in most tissues. It is synthesized throughout the nervous system and has both astroglial and neuronal origin.²

1. Johnson, EM. et al. (1998) Neuron 20: 245
2. Krieglstein, K. et al. (1998) J Neurosci Res. 53: 494