Anti-Human Suppressor of Cytokine Signaling 1 (NT) (SOCS1)

PN:S534

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Suppressor of Cytokine Signaling 1 (SOCS1) recognizes an epitope near the N-terminus of Human SOCS1. This polyclonal antibody was purified using affinity chromatography.

The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines.¹ SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase.² SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome.³ It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.⁴

1. Rakesh, K. et al. (2005) Biochem. Pharm. 70:649
2. O’Shea, JJ. et al. (2002) Cell 109:S121
3. Kile, BT. et al. (2002) Trends Biochem. Sci. 27:235
4. Mansell, A. et al. (2006) Nat. Immunol. 7:148