Anti-Human T Cell Cytokine Receptor (CT) (TCCR)

PN:T326

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human T Cell Cytokine Receptor (TCCR) recognizes an epitope near the C-terminus of Human TCCR. This polyclonal antibody was purified using affinity chromatography.

Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-γ and lymphotoxin-β that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned.^1,2 It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1.^1,2 TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-γ and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph nodes and peripheral blood leukocytes.

1. Chen, Q. et al. (2000) Nature 407(6806):916
2. Sprecher, CA. et al. (1998) Biophys. Res. Commun. 246(1):82