Anti-Human TCR Vα24-Jα18 (iNKT cell)- FITC

This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.

Next Day 2-8°C

Blue Laser (490 nm)

Clone 6B11 recognizes the invariant CDR3 region of the human Vα24-Jα18 TCR.

TCR Vα24-Jα18 antibody, 6B11, recognizes the CDR3 region of the V alpha 24 and J alpha 18 TCR alpha locus (Vα24-Jα18). The Vα24-Jα18 semi-invariant TCR is expressed on a highly conserved T cell subset, named invariant natural killer T (iNKT cells), which also express NK cell-associated molecules. The Vα24-Jα18 TCR recognizes lipid antigens, such as α-galactosylceramide (α-GalCer), presented by the MHC class I-like molecule CD1d¹. Following activation, iNKT cells rapidly proliferate and produce large amounts of IL-4, IFNγ, and cytolytic mediators^2,3. iNKT cells have both inflammatory and immunoregulatory functions and are implicated in anti-tumor immunity, protection against infections, suppression of autoimmunity, and the development of inflammatory diseases^4.

The Vα24-Jα18 TCR is expressed on iNKT cells.

Glycolipid loaded CD1d

1. Van Kaer L., et al. (2004) Nat Rev Immunol. 4(3):231-7
2. Teyton L., et al. (2006) Annu Rev Immunol. 25:297–336
3. Kronenberg M. (2004) Annu Rev Immunol. 23:877–900
4. Van Kaer L & Wu L. (2018) Front Immunol. 9:519