Anti-Human Tetratricopeptide Repeat Protein 5 (TTC5)

PN:T302

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Tetratricopeptide Repeat Protein 5 (TTC5) recognizes Human and Mouse TTC5. This polyclonal antibody was purified using affinity chromatography.

Tetratricopeptide repeat protein 5 (TTC5) is a member of a diverse group of functionally distinct proteins that are characterized by containing one or more tetratricopeptide repeats.¹ Each motif consists of two anti-parallel a-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that may serve to accommodate the complementary region of a target protein. While the exact function of TTC5 remains unclear, it is thought that the TPR motifs serve to mediate protein-protein interactions such as those seen with protein chaperones HSP70 and HSP90,² and some proteins involved in cell stress response signaling pathways such as protein phosphatase 5,³ suggesting that TTC5 may also function via protein-protein interactions mediated by its TPR motifs.

1. Blatch, GL. et al. (1999) BioEssays 21:932
2. Song, Y. et al. (2005) J. Biol. Chem. 280:34178
3. Yang, J. et al. (2005) EMBO J. 24:1