Anti-Human TIM-1 (Intermediate Domain)

PN:T348

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human TIM-1 recognizes an epitope in the intermediate domain of Human, Mouse and Rat TIM-1. This polyclonal antibody was purified using affinity chromatography.

The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.

1. Feigelstock, D. et al. (1998) J. Virol. 72:6621 2. Ichimura, T. et al. (1998) J. Biol. Chem. 273:4135 3. Meyers, J. H. et al. (2005) Trends Mol. Med. 11:362 4. Meyers, J. H. et al. (2005) Nat. Immunol. 6:455