Anti-Human TIM-4 (CT)

PN:T350

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human TIM-4 recognizes an epitope near the C-terminus of Human, Mouse and Rat TIM-4. This polyclonal antibody was purified using affinity chromatography.

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.

1. Meyers, JH. et al. (2005) Trends Mol. Med. 11:362
2. Meyers, JH. et al. (2005) Nat. Immunol. 6:455
3. Kuchroo, VK. et al. (2003) Nat. Rev. Immunol. 3:454-62
4. Shakhov, AN. et al. (2004) Eur J Immunol. 34(2):494-503.