Anti-Human TL1-A
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831895 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Anti-Human TNF-Ligand-Related Molecule 1-A (TL1-A) recognizes Human TL1-A. This polyclonal antibody was purified using affinity chromatography. Background TNF-ligand-related molecule 1A (TL1A), is an endothelium-derived T cell costimulator and a ligand for tumor necrosis factor receptor superfamily members DR3 and decoy receptor 3.1 TL1A binds to the death-domain receptor (DR)3 and provides costimulatory signals to activated lymphocytes. Through this interaction, TL1A induces secretion of IFN-γ. Blockade of the TL1A/DR3 pathway may offer therapeutic opportunities in Crohn's disease.2 PubMed References & Citations1. Wei, P. et al. (2003) J Biol Chem. 278: 39251 2. Cominelli, F. et al. (2006) PNAS 103: 8441 Technical Protocols Certificate of Analysis |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
