Anti-Human TRAIL R4 (Internal Domain)

PN:D266

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

Rabbit Anti-Human TNF-Related Apoptosis-Inducing Ligand Receptor 4 (TRAIL R4) recognizes Human TRAIL R4. This polyclonal antibody was purified using affinity chromatography.

TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.¹ TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.^1,2

1. Chan, FK. et al. (2005) Proc Natl Acad Sci USA 102: 18099
2. Sanlioglu, S. et al. (2005) BMC Cancer 5: 54