Anti-Insulin receptor (β subunit) Antibody (50104)
Anti-Insulin receptor (β subunit) Antibody (50104)
Product No.: 50104
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Clone 18-44 Target Insulin receptor (α subunit) Formats AvailableView All Product Type Monoclonal Alternate Names IR, EC 2.7.10.1, CD antigen CD220 [Cleaved into: Insulin receptor subunitα; Insulin receptor subunit β] Isotype Mouse IgG2b Applications IP , WB , Activtion , Inhibitor , Stimpulator |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Human placental insulin receptor Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by Protein G affinity chromatography Storage and Handling These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Monoclonal Antibody specific to human insulin receptor; low-level cross-reactivity with bovine
and rabbit insulin receptor. Function Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically rUniProtKB:P15208, PubMed:12138094, PubMed:16314505, PubMed:16831875, PubMed:8257688, PubMed:8276809, PubMed:8452530, PubMed:9428692}. NCBI Gene Bank ID UniProt.org Research Area Growth Factors, Cytokines, Receptors References & CitationsSoos et al. (1986) Biochem J 235: 199. Brindle et al. (1990) Biochem J 268: 615. Prigent et al. (1990) J Biol Chem 265: 9970 Technical Protocols  Activtion Inhibitor Stimpulator Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
