Anti-Interleukin-1 Receptor (IL-1R) Antibody (40103)
Anti-Interleukin-1 Receptor (IL-1R) Antibody (40103)
Product No.: 40103
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Clone IL1-31-113.1.1 Target Interleukin-1 Receptor (IL-1R) Formats AvailableView All Product Type Monoclonal Alternate Names IL-1R-1, IL-1RT-1, IL-1RT1, EC 3.2.2.6, CD121 antigen-like family member A, Interleukin-1 receptorα, IL-1R-α, Interleukin-1 receptor type I, p80, CD antigen CD121a [Cleaved into: Interleukin-1 receptor type 1, membrane form Isotype Mouse IgG2b Applications ELISA , IHC , RIA |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen The extracellular domain of the type I human IL-1 receptor (Genzyme Diagnostics). Product Concentration Lot Specific Formulation PBS, pH 7.4 State of Matter Liquid Product Preparation Purified by Protein G affinity chromatography Storage and Handling These antibodies are stable for at leastone (1) year at -20°C to -70 C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco ELISA: Can be used as capture reagents or second antibody at a concentration of 5 ug/ml
RIA: Concentrations of 20-30 ng/ml of these antibodies will bind radiolabeled IL-1 receptor in a radioimmunoassay format. Immunohistochemistry: IL-1 receptor can be detected on cultured cells using antibody concentrations of 10-100 ug/ml. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Monoclonal Antibody specific to cell surface
and soluble human Interleukin-1 receptor (IL-1R).
Specific epitopes are unknown, but they
do partially inhibit (30-50%) binding of
one another to IL-1 receptor. They do
not block binding of IL-1 to receptor,
and they do not cross-react with
receptors for human IL-2 or IL-4. Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). {PubMed:10653850, PubMed:10671496}. NCBI Gene Bank ID UniProt.org Research Area Growth Factors, Cytokines, Receptors References & CitationsTechnical Protocols  RIA Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
