Anti-Mouse CD86 – DyLight® 488

Anti-Mouse CD86 – DyLight® 488

Product No.: C2164

[product_table name="All Top" skus="C2164"]

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Clone
GL1
Target
B7-2
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
B7-2, B70, Ly-58, CD-86
Isotype
IgG2a κ
Applications
FC
,
ICC

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Select Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Rat
Immunogen
Purified Recombinant Mouse CD86 (>98%)
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Excitation Laser
Blue Laser (493 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Clone GL-1 recognizes an epitope on mouse CD86.
Background
CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.
Antigen Distribution
CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes.
Ligand/Receptor
CD28, CD152 (CTLA-4)
PubMed
NCBI Gene Bank ID
Research Area
Cell Biology
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Costimulatory Molecules
.
Immunology
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Neuroinflammation
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Neuroscience Cell Markers

References & Citations

1. Hathcock, K.S. et al.. (1993) Science 262(5135:905-7)
Flow Cytometry
ICC

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.