Anti-Mouse CD86 – Purified

LPS activated DBA/2J mouse B cells.

This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

This purified antibody is stable when stored at 2-8°C. Do not freeze.

Next Day 2-8°C

Clone GL-1 recognizes an epitope on mouse CD86.

CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.

CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes.

CD28, CD152 (CTLA-4)

1. Hathcock, K.S. et al.. (1993) Science 262(5135:905-7)