Anti-Mouse CD122 (IL-2Rβ) – Biotin
Anti-Mouse CD122 (IL-2Rβ) – Biotin
Product No.: C2327
- -
- -
Clone TM-β1 Target CD122 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Interleukin 2 receptor β chain, IL-2/15Rb Isotype IgG2b |
- -
- -
Antibody DetailsProduct DetailsReactive Species Human Host Species Rat Immunogen Rat T-cell line expressing Mouse IL-2Rβ Product Concentration 0.5 mg/ml Formulation This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This biotinylated antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2829418 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this TM-β1 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone TM-β1 recognizes an epitope on mouse CD122. Background CD122 is a 70-75 kD IL-2 receptor β chain that is a type I membrane protein. CD122 is involved in T cell-mediated immune responses and its activation increases proliferation of CD8+ effector T cells. It exists in three forms with varying degrees of binding affinity with IL-2. The low affinity form is a monomer of the α subunit and has no involvement in signal transduction. The intermediate affinity form is a γ/β heterodimer and the high affinity form is an α/β/γ heterotrimer. The intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. This protein also interacts with the IL-15 receptor. Antigen Distribution CD122 is expressed on NK cells and at lower levels by T lymphocytes, B lymphocytes, monocytes, and macrophages. Ligand/Receptor IL-2, IL-15 PubMed NCBI Gene Bank ID UniProt.org Research Area Immunology References & Citations1. Burchill, MA. et al. (2007) J. Immunol. 178:280 2. Friedmann, MC. et al. (1996) Proc. Natl. Acad. Sci. (USA) 93:2077 3. Leonard, WJ. et al. (1987) Science 238:75 |
Formats Available
- -
- -
Prod No. | Description |
|---|---|
C2329 | |
C2327 | |
C2326 | |
C2328 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
