Anti-Mouse CD127 (IL-7Rα) – Purified
Anti-Mouse CD127 (IL-7Rα) – Purified
Product No.: C2133
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Clone A7R34 Target CD127 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names IL-7Rα, Interleukin-7 receptor alpha, IL-7Rα chain Isotype IgG2a κ Applications FA , FC , IF Staining , IHC FF , IP , WB |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Recombinant Mouse IL-7ra Product Concentration 0.5 mg/ml Formulation This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2829215 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this A7R34 antibody for staining cells in flow cytometry is ≤ 1 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Additional Applications Reported In Literature ? FA IF Staining IHC (Frozen) IP WB Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone A7R34 recognizes an epitope on mouse CD127. Background CD127 (IL7R-α) is a 60-90 kD type I cytokine receptor involved in the regulation of lymphopoiesis. The active receptor is an α/γ chain heterodimer. The common γ chain, which also associates with the IL-2 receptor, serves mainly to activate signal transduction via the IL7R complex. CD127 also interacts with the Thymic Stromal Lymphopoietin Receptor (TSLPR). CD127 determines signaling events via its association with cytoplasmic signaling molecules and has been reported to be a useful marker for identifying memory and effector T cells. Antigen Distribution IL-7Rα is expressed on bone marrow lymphoid precursors, pro-B cells, monocytes/macrophages, NK-cells, naïve T cells, memory CD4+ and CD8+ T cells, intestinal colorectal and renal carcinoma cell lines, and keratinocytes. Ligand/Receptor IL-7 PubMed NCBI Gene Bank ID UniProt.org Research Area Immunology References & Citations1. Fry TJ et al. (2005) J Immunol. 174: 6571
2. Murre C et al. (2002) Embo J. 21: 103 Technical ProtocolsFA  IF Staining IHC FF   Certificate of Analysis |
Formats Available
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Prod No. | Description |
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C2228 | |
C2226 | |
C2225 | |
C2229 | |
C2230 | |
C2231 | |
C2232 | |
C2224 | |
C2223 | |
C2133 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
