Anti-Mouse CD19 – DyLight® 650
Anti-Mouse CD19 – DyLight® 650
Product No.: C2113
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Clone 1D3 Target CD19 Formats AvailableView All Product Type Monoclonal Antibody Isotype IgG2a Applications FC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Fusion of NS-1 Myeloma cells with spleen cells Product Concentration 0.2 mg/ml Formulation This DyLight® 650 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 650 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Red Laser (652 nm) RRIDAB_2829196 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 1D3 recognizes an epitope on mouse CD19. Background CD19 is a 95 kD transmembrane glycoprotein and member of the Ig superfamily. The antigen serves as an adaptor protein; drawing cytoplasmic signaling proteins to the membrane. It works via the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Because of its presence on all B cells, CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for the immunotherapy of lymphoproliferative disorders. Emerging studies indicate that CD19 plays an active role in fueling the growth of these cancers, most notably by stabilizing the concentrations of the MYC oncoprotein, making CD19 an attractive therapeutic target with respect to its downstream signaling. Antigen Distribution CD19 is expressed in the majority of Pro-B cells to mature B cells (during development) and follicular dendritic cells. Plasma cells do not express CD19. Ligand/Receptor CD21, CD81, Leu-13. PubMed NCBI Gene Bank ID UniProt.org Research Area Immunology References & CitationsTechnical ProtocolsCertificate of Analysis |
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