Anti-Mouse CD252 (OX40L) – Purified
Anti-Mouse CD252 (OX40L) – Purified
Product No.: C2146
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Clone RM134L Target OX 40 Ligand Formats AvailableView All Product Type Monoclonal Antibody Alternate Names OX 40 Ligand, OX40L, CD134L, TNFSF4 Isotype IgG2b Applications FC , IHC FF |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Rat NRK-52E cell line transfected with mouse OX-40L gene Product Concentration 0.5 mg/ml Formulation This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Product Preparation This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2829229 Applications and Recommended Usage? Quality Tested by Leinco For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. Each lot of this antibody is quality control tested Additional Applications Reported In Literature ? Additional reported applications (for the relevant formats) include: ICH-FFPE B:The RM134L antibody can block the costimulatory activity of OX40L. The Purified GOLD or PLATINUM part numbers are recommended for functional assays. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone RM134L, Anti-Mouse CD252 (OX40L) recognizes an epitope on Mouse CD252. Background CD252 is a 35 kD member of the TNF superfamily and is the ligand for OX-40, which is primarily found on activated T cells. The CD252/OX-40 pair contributes to B-cell and T-cell interaction during the immune response. Both proliferative and IL-2 production responses of activated T cells are enhanced via OX-40 antigen stimulation, while proliferation and Ig secretion by activated B cells is enhanced via CD252 stimulation. Hence, because both T cells and B cells are activated in cross-linking, the CD252/OX-40 pair is considered reciprocally costimulatory. Antigen Distribution Activated B cells, antigen-presenting cells Ligand/Receptor OX40 (CD134) Function B-cell/T-cell interaction, costimulation NCBI Gene Bank ID UniProt.org Research Area Costimulatory Molecules . Immunology References & CitationsTechnical Protocols IHC FF Certificate of Analysis |
Formats Available
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Prod No. | Description |
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C2338 | |
C2339 | |
C2342 | |
C2345 | |
C2336 | |
C2146 | |
C2340 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
