Anti-Mouse CD28 – DyLight® 488
Anti-Mouse CD28 – DyLight® 488
Product No.: C1701
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Clone 37.51 Target CD28 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names MGC138290, Tp44 Isotype IgG Applications FC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Syrian Hamster Immunogen Purified Recombinant Mouse CD28 (>98%) Product Concentration 0.2 mg/ml Formulation This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Blue Laser (493 nm) RRIDAB_2828762 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this 37.51 antibody for staining cells in flow cytometry is ≤ 0.25 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Additional Reported Applications For Relevant Conjugates ? B Cosim IP IHC (Frozen) For specific conjugates of this clone, review literature for suggested application details. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 37.51 recognizes an epitope on mouse CD28. Background CD28 is a 44 kD glycoprotein and a member of the Ig superfamily. In its capacity as a costimulatory receptor, CD28 produces co-stimulatory signals necessary for T cell activation and survival. CD28 is the only B7 receptor constitutively expressed on naive T cells. Without having this CD28/B7 interaction, T cells will fail to respond to their specific antigen when coming in contact with an MHC/antigen complex and thus, are said to be anergic. Antigen Distribution CD28 is expressed on thymocytes, CD4+, CD8+ peripheral T cells, NK cells. Ligand/Receptor CD80 (B7-1), CD86 (B7-2) PubMed NCBI Gene Bank ID UniProt.org Research Area Costimulatory Molecules . Immunology References & Citations1. Gross, J. A. et al. (1992) J. Immunol. 149:380 Technical Protocols Certificate of Analysis |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
